{"id":5414,"date":"2026-10-18T02:10:37","date_gmt":"2026-10-18T02:10:37","guid":{"rendered":"https:\/\/legitchem.com\/?post_type=product&p=5414"},"modified":"2026-10-20T11:37:25","modified_gmt":"2026-10-20T11:37:25","slug":"o-pcp-2-oxo-pcm","status":"publish","type":"product","link":"https:\/\/legitchem.com\/es\/o-pcp-2-oxo-pcm\/","title":{"rendered":"O-PCP (2-Oxo-PCM)"},"content":{"rendered":"

O-PCP (2-Oxo-PCM) \u2013 Comprehensive Research Compound Overview<\/strong><\/h1>\n

O-PCP (2-Oxo-PCM)<\/strong><\/a>, also known as 2-Oxo-Phenylcyclohexylamine<\/strong>, is a novel dissociative compound<\/strong> belonging to the arylcyclohexylamine<\/strong> class. Structurally related to phencyclidine (PCP)<\/strong> and ketamine<\/strong>, this research chemical is of growing interest among analytical chemists and neuropharmacology researchers exploring the NMDA receptor antagonist<\/strong> family of compounds. O-PCP has garnered attention for its unique chemical properties<\/strong>, potential pharmacological activity<\/strong>, and structural significance<\/strong> in the study of dissociative anesthetics and their analogs.<\/p>\n

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Chemical Name:<\/strong> 2-Oxo-PCM (O-PCP)
Synonyms:<\/strong> 2-Oxo-Phenylcyclohexylamine, O-PCM
IUPAC Name:<\/strong> 1-(1-Phenylcyclohexyl)pyrrolidin-2-one
Molecular Formula:<\/strong> C\u2081\u2087H\u2082\u2083NO
Molecular Weight:<\/strong> 257.37 g\/mol
Class:<\/strong> Arylcyclohexylamine derivative
Purity:<\/strong> \u2265 98% (analytical standard)
Form:<\/strong> Fine crystalline powder
Intended Use:<\/strong> For laboratory research and analytical reference only<\/p>\n<\/blockquote>\n

Understanding O-PCP (2-Oxo-PCM): Structure and Mechanism<\/strong><\/h2>\n

O-PCP (2-Oxo-PCM) is a structural analog of PCP (phencyclidine)<\/strong><\/a>, with a key difference being the presence of an oxygen atom at the 2-position<\/strong>, forming a ketone group (oxo substitution)<\/strong>. This modification has a notable impact on the molecule\u2019s lipophilicity, binding affinity, and receptor interaction profile<\/strong>.<\/p>\n

Like other compounds in the arylcyclohexylamine family, O-PCP is believed to function primarily as an NMDA (N-Methyl-D-Aspartate) receptor antagonist<\/strong>, a receptor type involved in synaptic plasticity, learning, and memory. NMDA receptor antagonists inhibit excitatory neurotransmission mediated by glutamate, which can produce dissociative effects<\/strong> and altered perception in animal studies.<\/p>\n

Researchers value O-PCP (2-Oxo-PCM) for its intermediate position<\/strong> between known dissociatives such as ketamine, MXE (methoxetamine), and PCP<\/strong>, allowing comparative studies on structure\u2013activity relationships (SAR). Its unique oxo substitution provides insights into how molecular configuration affects receptor selectivity, metabolic pathways, and central nervous system (CNS) activity<\/strong>.<\/p>\n

Research Applications of O-PCP (2-Oxo-PCM)<\/strong><\/h2>\n

O-PCP is primarily used as a reference material<\/strong> in analytical chemistry<\/strong>, forensic toxicology<\/strong>, and pharmacological research<\/strong>. Its applications include:<\/p>\n

1. Analytical Reference Standard<\/strong><\/h3>\n

O-PCP (2-Oxo-PCM) serves as a benchmark compound<\/strong> for the identification and differentiation of novel arylcyclohexylamine derivatives in laboratory testing. It assists in developing and validating GC-MS, LC-MS, and HPLC<\/strong> methods used by forensic and analytical laboratories.<\/p>\n

2. Neuropharmacological Studies<\/strong><\/h3>\n

Due to its potential NMDA receptor antagonism, O-PCP is utilized in receptor binding assays<\/strong> and pharmacodynamic studies<\/strong> to understand how structural analogs modulate glutamatergic neurotransmission. Researchers explore its comparative potency<\/strong>, duration of action<\/strong>, and binding selectivity<\/strong> relative to other dissociatives.<\/p>\n

3. Structure\u2013Activity Relationship (SAR) Investigations<\/strong><\/h3>\n

O-PCP\u2019s oxo substitution makes it valuable in SAR research<\/strong>, allowing scientists to evaluate how small changes in molecular structure influence pharmacological activity. Such studies contribute to the broader understanding of arylcyclohexylamine derivatives<\/strong> and potential therapeutic implications.<\/p>\n

4. Forensic Toxicology and Substance Profiling<\/strong><\/h3>\n

As new psychoactive substances (NPS) emerge globally, O-PCP (2-Oxo-PCM) is examined for its potential presence in illicit markets. Analytical labs use it to create reference spectra and data for substance identification and detection protocols<\/strong>.<\/p>\n

Chemical Properties and Formulation O-PCP (2-Oxo-PCM)<\/strong><\/h2>\n

O-PCP (2-Oxo-PCM) typically appears as a fine white to off-white crystalline powder<\/strong>. It exhibits moderate solubility<\/strong> in organic solvents such as ethanol, methanol, and DMSO, and limited solubility in water.<\/p>\n

The compound\u2019s purity (\u226598%)<\/strong> ensures reliability in laboratory conditions, minimizing confounding variables in experimental outcomes. It is highly recommended to store O-PCP in a cool, dry, and airtight environment<\/strong>, away from direct sunlight and moisture to preserve stability.<\/p>\n

Safety, Handling, and Legal Status<\/strong><\/h2>\n

O-PCP (2-Oxo-PCM) is intended strictly for laboratory and research use<\/strong>. It is not approved for human or veterinary consumption<\/strong>, clinical use<\/strong>, or any form of in vivo experimentation<\/strong>. Researchers should handle O-PCP (2-Oxo-PCM) with caution, using appropriate protective equipment<\/strong> (gloves, goggles, lab coat) and following institutional safety protocols for chemical handling and disposal.<\/p>\n

As with many arylcyclohexylamines, legal classification varies by region<\/strong>. Some jurisdictions may regulate or restrict O-PCP (2-Oxo-PCM) under analog or controlled substance laws. It is the researcher\u2019s responsibility to ensure compliance with local and national regulations<\/strong> before purchase or use.<\/p>\n

Why Researchers Choose O-PCP (2-Oxo-PCM)<\/strong><\/h2>\n
    \n
  • \n

    High Purity:<\/strong> Guaranteed \u226598% analytical-grade material suitable for precise lab work.<\/p>\n<\/li>\n

  • \n

    Reliable Quality:<\/strong> Consistent formulation ensures reproducible research outcomes.<\/p>\n<\/li>\n

  • \n

    Scientific Value:<\/strong> Ideal for comparative and receptor-binding studies.<\/p>\n<\/li>\n

  • \n

    Analytical Utility:<\/strong> Supports the development of reference data and testing standards.<\/p>\n<\/li>\n

  • \n

    Secure Packaging:<\/strong> Delivered in sealed, moisture-resistant containers to ensure product integrity.<\/p>\n<\/li>\n<\/ul>\n

    Conclusion<\/strong><\/h2>\n

    O-PCP (2-Oxo-PCM)<\/strong> stands out as a valuable research chemical<\/strong> in the exploration of arylcyclohexylamine pharmacology and NMDA receptor antagonism. Its distinctive 2-oxo substitution<\/strong> offers a meaningful avenue for understanding molecular modifications and their impact on receptor activity, potency, and neurochemical effects.<\/p>\n

    With growing interest in novel dissociative analogs<\/strong>, O-PCP (2-Oxo-PCM) continues to play a pivotal role in both analytical and neurochemical research<\/strong>, enabling deeper insights into the mechanisms underlying dissociative compounds.<\/p>\n

    \n

    Disclaimer:<\/strong> O-PCP (2-Oxo-PCM) is sold for laboratory research purposes only<\/strong>. It is not intended for human consumption<\/strong>, medical use, or any non-scientific purpose. Always verify local laws and handle with appropriate laboratory safety protocols.<\/p>\n<\/blockquote>","protected":false},"excerpt":{"rendered":"

    O-PCP (2-Oxo-PCM), also known as 2-Oxo-PCM<\/strong>, is a dissociative research chemical<\/strong> belonging to the arylcyclohexylamine class, structurally related to PCP and ketamine<\/strong>. Researchers value O-PCP for its unique pharmacological profile<\/strong>, offering insight into NMDA receptor antagonism and its potential applications in neurochemical and psychopharmacological studies<\/strong>.<\/p>\n

    This compound is intended strictly for laboratory research purposes<\/strong> and is not for human consumption<\/strong>. With high purity and reliable quality, O-PCP is ideal for professionals investigating novel dissociative mechanisms<\/strong>, receptor binding properties, and comparative behavioral models.<\/p>\n

    Key Features:<\/strong><\/p>\n

      \n
    • \n

      Chemical name: 2-Oxo-PCM (O-PCP)<\/strong><\/p>\n<\/li>\n

    • \n

      Class: Arylcyclohexylamine dissociative<\/strong><\/p>\n<\/li>\n

    • \n

      Purity: \u226598% (lab-tested)<\/strong><\/p>\n<\/li>\n

    • \n

      Form: Powder \/ crystalline<\/strong><\/p>\n<\/li>\n

    • \n

      For research and analytical use only<\/strong><\/p>\n<\/li>\n<\/ul>","protected":false},"featured_media":5423,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center 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