{"id":5392,"date":"2026-10-18T02:10:36","date_gmt":"2026-10-18T02:10:36","guid":{"rendered":"https:\/\/legitchem.com\/?post_type=product&p=5392"},"modified":"2026-10-20T11:37:25","modified_gmt":"2026-10-20T11:37:25","slug":"4-ho-met","status":"publish","type":"product","link":"https:\/\/legitchem.com\/it\/4-ho-met\/","title":{"rendered":"4-HO-MET"},"content":{"rendered":"

4-HO-MET (4-Hydroxy-N-methyl-N-ethyltryptamine) \u2013 Detailed Overview for Research and Analysis<\/strong><\/h2>\n

4-HO-MET<\/strong><\/a>, also known as 4-Hydroxy-N-methyl-N-ethyltryptamine<\/strong>, is a synthetic psychedelic compound<\/strong> belonging to the tryptamine class<\/strong>. Structurally related to psilocin<\/strong> (the active metabolite of psilocybin found in magic mushrooms), 4-HO-MET has gained attention among researchers and psychopharmacologists for its unique psychoactive profile<\/strong>, potent visual effects<\/strong>, and short-to-moderate duration<\/strong> of action.<\/p>\n

With growing interest in novel tryptamines, 4-HO-MET remains a notable subject for scientific exploration<\/strong><\/a>, particularly in studies focused on serotonergic receptor interactions<\/strong>, perceptual alteration<\/strong>, and psychological effects<\/strong> associated with psychedelic substances.<\/p>\n

\n

Chemical Profile and Structure<\/strong><\/h3>\n
    \n
  • \n

    Chemical Name:<\/strong> 4-Hydroxy-N-methyl-N-ethyltryptamine<\/p>\n<\/li>\n

  • \n

    Common Names:<\/strong> 4-HO-MET, Metocin<\/p>\n<\/li>\n

  • \n

    Molecular Formula:<\/strong> C13H18N2O<\/p>\n<\/li>\n

  • \n

    Molecular Weight:<\/strong> 218.29 g\/mol<\/p>\n<\/li>\n

  • \n

    IUPAC Name:<\/strong> 3-[2-(ethyl(methyl)amino)ethyl]-1H-indol-4-ol<\/p>\n<\/li>\n

  • \n

    Chemical Class:<\/strong> Tryptamine<\/p>\n<\/li>\n<\/ul>\n

    4-HO-MET is a hydroxylated analogue<\/strong> of 4-hydroxy-N-methyl-N-ethyltryptamine, and both are close structural relatives of psilocin (4-HO-DMT)<\/strong>. The compound\u2019s chemical similarity to natural tryptamines gives it a comparable pharmacological mechanism<\/strong>, acting primarily as a serotonin receptor agonist<\/strong>, especially at the 5-HT2A receptor<\/strong> \u2014 the same receptor implicated in the psychedelic effects of LSD, psilocybin, and DMT.<\/p>\n

    \n

    Origins and Development<\/strong><\/h3>\n

    4-hydroxy-N-methyl-N-ethyltryptamine was first synthesized by Alexander Shulgin<\/strong>, the pioneering chemist and author of TiHKAL: Tryptamines I Have Known and Loved<\/em>. In his documentation, Shulgin described 4-HO-MET as producing effects similar to psilocybin<\/strong>, but with a more vivid visual and less introspective character<\/strong>. Since its synthesis, the compound has been used primarily in psychopharmacological research<\/strong> and analytical chemistry<\/strong>, offering valuable insights into structure-activity relationships<\/strong> within the tryptamine family.<\/p>\n

    \n

    Pharmacology and Mechanism of Action<\/strong><\/h3>\n

    Like other substituted tryptamines, 4-hydroxy-N-methyl-N-ethyltryptamine acts as a partial agonist at serotonin receptors<\/strong>, particularly 5-HT2A, 5-HT2C, and 5-HT1A<\/strong>. Activation of these receptors in the brain is believed to induce altered sensory perception<\/strong>, emotional intensification<\/strong>, and changes in cognitive processing<\/strong> characteristic of psychedelic experiences.<\/p>\n

    At the molecular level, the hydroxy group at the 4-position<\/strong> of the indole ring enhances its similarity to psilocin, contributing to its affinity for serotonergic pathways<\/strong> and its psychedelic potency<\/strong>.<\/p>\n

    Researchers studying 4-HO-MET often focus on its:<\/p>\n

      \n
    • \n

      Binding affinity across serotonin receptor subtypes<\/strong><\/p>\n<\/li>\n

    • \n

      Metabolic pathways and elimination half-life<\/strong><\/p>\n<\/li>\n

    • \n

      Potential therapeutic implications in neuroscience<\/strong><\/p>\n<\/li>\n<\/ul>\n

      These parameters make 4-hydroxy-N-methyl-N-ethyltryptamine a valuable compound in research settings<\/strong>, particularly for studies investigating consciousness, perception, and neurochemical modulation<\/strong>.<\/p>\n

      \n

      Visual and Sensory Characteristics<\/strong><\/h3>\n

      In anecdotal research and controlled trials, 4-HO-MET is known for producing:<\/p>\n

        \n
      • \n

        Intensified visual patterns and color enhancement<\/strong><\/p>\n<\/li>\n

      • \n

        Mild to moderate euphoria<\/strong><\/p>\n<\/li>\n

      • \n

        Altered time perception<\/strong><\/p>\n<\/li>\n

      • \n

        Enhanced tactile sensitivity<\/strong><\/p>\n<\/li>\n

      • \n

        Light body energy or stimulation<\/strong><\/p>\n<\/li>\n<\/ul>\n

        Unlike some other tryptamines that induce strong introspection or emotional depth, 4-hydroxy-N-methyl-N-ethyltryptamine tends to produce more externally oriented and visually dynamic experiences<\/strong>, making it a unique research analog<\/strong> for comparative psychedelic studies.<\/p>\n

        \n

        Duration and Dosage (for Research Contexts Only)<\/strong><\/h3>\n

        Reports from research and analytical review suggest the onset<\/strong> of 4-hydroxy-N-methyl-N-ethyltryptamine\u2019s effects occurs within 20 to 45 minutes<\/strong>, peaking at around 1 to 2 hours<\/strong>, and subsiding over 4 to 6 hours<\/strong>.<\/p>\n

        Although 4-HO-MET is not approved for human consumption<\/strong>, laboratory and analytical observations typically note that it exhibits dose-dependent effects<\/strong>:<\/p>\n

          \n
        • \n

          Low-range exposure:<\/strong> light visual enhancement, subtle mood alteration<\/p>\n<\/li>\n

        • \n

          Moderate-range exposure:<\/strong> open-eye visuals, synesthesia, mood elevation<\/p>\n<\/li>\n

        • \n

          High-range exposure:<\/strong> immersive visuals, euphoria, altered spatial perception<\/p>\n<\/li>\n<\/ul>\n

          Researchers must exercise strict laboratory safety standards<\/strong> and ensure accurate volumetric measurement<\/strong> during any study involving this compound.<\/p>\n

          \n

          Legal Status and Compliance Notice<\/strong><\/h3>\n

          The legal classification of 4-HO-MET<\/strong> varies across jurisdictions. In many countries, it remains unscheduled but controlled under analogue laws<\/strong>, meaning it may be regulated as a chemical analogue of psilocin<\/strong> or other tryptamines.<\/p>\n

          Before conducting any form of research, users must confirm the legal standing<\/strong> of 4-hydroxy-N-methyl-N-ethyltryptamine within their region or institution<\/strong>. This compound is intended strictly for scientific, analytical, or forensic research<\/strong> and not for human or veterinary use<\/strong>.<\/p>\n

          \n

          Storage and Stability<\/strong><\/h3>\n

          For optimal stability, 4-HO-MET should be stored in:<\/p>\n

            \n
          • \n

            A cool, dry environment<\/strong><\/p>\n<\/li>\n

          • \n

            Airtight, light-resistant containers<\/strong><\/p>\n<\/li>\n

          • \n

            Temperature-controlled conditions<\/strong>, ideally below 20\u00b0C<\/p>\n<\/li>\n<\/ul>\n

            Proper storage ensures chemical integrity<\/strong> and accurate results<\/strong> during analytical testing.<\/p>\n

            \n

            Why Researchers Choose 4-HO-MET<\/strong><\/h3>\n
              \n
            1. \n

              Structural similarity to psilocin<\/strong> \u2013 making it ideal for comparative studies.<\/p>\n<\/li>\n

            2. \n

              Predictable pharmacological response<\/strong> \u2013 useful for mapping receptor pathways.<\/p>\n<\/li>\n

            3. \n

              Shorter duration<\/strong> \u2013 allowing easier monitoring in controlled settings.<\/p>\n<\/li>\n

            4. \n

              Well-documented background<\/strong> \u2013 detailed in Shulgin\u2019s chemical literature.<\/p>\n<\/li>\n<\/ol>\n

              Because of these attributes, 4-HO-MET continues to be a highly regarded tryptamine<\/strong> in modern psychedelic research.<\/p>\n

              \n

              Conclusion<\/strong><\/h3>\n

              4-HO-MET stands at the intersection of chemistry, neuroscience, and pharmacology<\/strong>, offering a compelling opportunity for scientists to explore the complex relationship between serotonin signaling and human perception<\/strong>. Its structural resemblance to natural tryptamines<\/strong>, combined with manageable duration and potency<\/strong>, makes it a preferred research chemical<\/strong> for those studying psychedelic mechanisms<\/strong> and receptor dynamics<\/strong>.<\/p>\n

              When sourced responsibly and used within proper legal and ethical boundaries, 4-HO-MET serves as a valuable compound for analytical and psychopharmacological research<\/strong> aimed at deepening our understanding of the human mind and its neurochemical foundations<\/strong>.<\/p>\n","protected":false},"excerpt":{"rendered":"

              4-HO-MET (4-hydroxy-N-methyl-N-ethyltryptamine) is a synthetic psychedelic compound from the tryptamine family, closely related to psilocin and known for its visual and euphoric effects in research settings. Often compared to naturally occurring psilocybin, 4-HO-MET is valued by researchers for its ability to provide insight into serotonin receptor activity and altered states of consciousness.<\/p>\n

              Key Features:<\/strong><\/p>\n

                \n
              • \n

                Chemical Name:<\/strong> 4-hydroxy-N-methyl-N-ethyltryptamine<\/p>\n<\/li>\n

              • \n

                Form:<\/strong> Powder or crystal (purity \u226598%)<\/p>\n<\/li>\n

              • \n

                Class:<\/strong> Tryptamine analogue<\/p>\n<\/li>\n

              • \n

                Research Use:<\/strong> Neuropharmacological and behavioral studies<\/p>\n<\/li>\n

              • \n

                Storage:<\/strong> Keep in a cool, dry environment away from sunlight<\/p>\n<\/li>\n<\/ul>\n

                This compound is intended strictly for laboratory and analytical research<\/strong>. It is not approved for human consumption<\/strong> or medical use.<\/p>","protected":false},"featured_media":5419,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"product_brand":[],"product_cat":[704],"product_tag":[],"class_list":["post-5392","product","type-product","status-publish","has-post-thumbnail","product_cat-psychedelics","desktop-align-left","tablet-align-left","mobile-align-left","first","instock","shipping-taxable","purchasable","product-type-variable"],"spectra_blocks_featured_image_url":{"thumbnail":{"url":"https:\/\/legitchem.com\/wp-content\/uploads\/2026\/10\/image-150x150.webp","width":150,"height":150},"medium":{"url":"https:\/\/legitchem.com\/wp-content\/uploads\/2026\/10\/image-300x225.webp","width":300,"height":225},"medium_large":{"url":"https:\/\/legitchem.com\/wp-content\/uploads\/2026\/10\/image-768x576.webp","width":768,"height":576},"large":{"url":"https:\/\/legitchem.com\/wp-content\/uploads\/2026\/10\/image-1024x768.webp","width":1024,"height":768},"full":{"url":"https:\/\/legitchem.com\/wp-content\/uploads\/2026\/10\/image.webp","width":1174,"height":881}},"spectra_blocks_author_info":{"display_name":"admin","avatar_url":"https:\/\/secure.gravatar.com\/avatar\/ade78b2f1dbfd013a9b79d40a5a19e28715abc7f064ec0be4473fef85c8ecd63?s=96&d=mm&r=g","author_link":"https:\/\/legitchem.com\/it\/author\/admin\/","description":""},"_links":{"self":[{"href":"https:\/\/legitchem.com\/it\/wp-json\/wp\/v2\/product\/5392","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/legitchem.com\/it\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/legitchem.com\/it\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/legitchem.com\/it\/wp-json\/wp\/v2\/comments?post=5392"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/legitchem.com\/it\/wp-json\/wp\/v2\/media\/5419"}],"wp:attachment":[{"href":"https:\/\/legitchem.com\/it\/wp-json\/wp\/v2\/media?parent=5392"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/legitchem.com\/it\/wp-json\/wp\/v2\/product_brand?post=5392"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/legitchem.com\/it\/wp-json\/wp\/v2\/product_cat?post=5392"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/legitchem.com\/it\/wp-json\/wp\/v2\/product_tag?post=5392"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}