MK-801 (Dizocilpine) is a non-competitive NMDA receptor antagonist widely referenced in neuroscience and pharmacological research. In laboratory settings, it is used for investigating glutamate receptor function, neurotoxicity models, and comparative NMDA receptor studies.
Within the EU and Netherlands, MK-801 is handled strictly as a laboratory reference material with no approved medical, therapeutic, or commercial applications.
Research & Chemical Summary
| Attribute | Details |
|---|---|
| Common Name | MK-801 |
| Chemical Name | Dizocilpine maleate / MK-801 hydrogen maleate |
| Chemical Class | NMDA receptor antagonist |
| Research Status | Research Chemical 🧪 |
| Physical Form | Powder |
| Intended Use | Laboratory & analytical research only |
| Region Focus | Europe / Netherlands (EU) |
Scientific & Analytical Context
MK-801 is commonly used in research for:
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Neuropharmacological studies
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NMDA receptor function analysis
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Neurotoxicity and neuroprotection experiments
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Analytical method development (HPLC, LC/MS)
Research publications focus primarily on mechanistic studies of NMDA receptor inhibition, with limited formal toxicology data outside controlled lab settings.
Chemical Specifications
| Property | Value |
|---|---|
| Molecular Formula | C₁₉H₂₇N₃O·HCl |
| Molecular Weight | ~337.91 g/mol (hydrochloride salt) |
| CAS Number | 77086-22-7 |
| IUPAC Name | (+)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine |
| PubChem CID | 1502 |
Structural Identifiers
| Identifier | Data |
|---|---|
| SMILES | CN1C2=CC=CC=C2C3=C1C=CC=C3 |
| InChIKey | SWIYHPRUBOZFLV-UHFFFAOYSA-N |
Key Research Characteristics
| Feature | Summary |
|---|---|
| Compound Type | NMDA receptor antagonist |
| Structural Interest | Mechanistic studies of glutamate receptors |
| Research Focus | Neuropharmacology, receptor binding, analytical studies |
| Documentation | CAS, molecular & structural data |
Compliance & Handling Notice
This product is supplied exclusively for laboratory and analytical research purposes.
Not intended for human or animal use.
