Clomifene, also known as Clomiphene, is a medication that belongs to the class of selective estrogen receptor modulators (SERMs). It is primarily used in the treatment of female infertility by inducing ovulation. Clomifene is available in the form of tablets and is usually prescribed for a period of five days. It works by increasing the levels of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) in the body, which leads to the release of an egg from the ovary.
Clomifene is known for its efficacy in inducing ovulation in women who have irregular menstrual cycles or who do not ovulate regularly. It can also be used in women who have polycystic ovary syndrome (PCOS), which is a condition that affects the functioning of the ovaries. Clomifene can help to increase the chances of conception and can be an effective treatment for infertility caused by these conditions. In addition, Clomifene has been used off-label for the treatment of male infertility.
Clomifene is primarily used in the treatment of female infertility caused by ovulatory dysfunction, such as irregular menstrual cycles or PCOS. It can be used in women who have unexplained infertility, meaning that there is no identifiable cause for their inability to conceive. Clomifene is also used in assisted reproductive technologies (ART) such as in-vitro fertilization (IVF) to increase the number of eggs that can be retrieved.
In men, Clomifene is sometimes used off-label to treat infertility caused by low testosterone levels. It can help to increase the production of testosterone by the testes and improve sperm count and motility. Clomifene has also been used to treat gynecomastia, a condition in which breast tissue develops in men.
Clomifene should only be used under the supervision of a qualified healthcare professional. It can cause side effects such as hot flashes, mood changes, headaches, and vaginal dryness. In rare cases, Clomifene can cause ovarian hyperstimulation syndrome (OHSS), a condition in which the ovaries become swollen and painful. OHSS can be a serious condition and requires medical attention. Clomifene can also increase the risk of multiple pregnancies, which can lead to complications during pregnancy and childbirth.
Clomifene should not be used by women who are already pregnant or who have liver disease. It should be used with caution in women who have a history of ovarian cysts, endometriosis, or thyroid problems. In addition, Clomifene can interact with other medications, so it is important to inform your healthcare provider of all the medications you are taking before starting treatment with Clomifene.
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