MK-801 (Dizocilpine) is a non-competitive NMDA receptor antagonist widely referenced in neuroscience and pharmacological research. In laboratory settings, it is used for investigating glutamate receptor function, neurotoxicity models, and comparative NMDA receptor studies.

Within the EU and Netherlands, MK-801 is handled strictly as a laboratory reference material with no approved medical, therapeutic, or commercial applications.

Research & Chemical Summary

Attribute	Details
Common Name	MK-801
Chemical Name	Dizocilpine maleate / MK-801 hydrogen maleate
Chemical Class	NMDA receptor antagonist
Research Status	Research Chemical 🧪
Physical Form	Powder
Intended Use	Laboratory & analytical research only
Region Focus	Europe / Netherlands (EU)

Scientific & Analytical Context

MK-801 is commonly used in research for:

Neuropharmacological studies
NMDA receptor function analysis
Neurotoxicity and neuroprotection experiments
Analytical method development (HPLC, LC/MS)

Research publications focus primarily on mechanistic studies of NMDA receptor inhibition, with limited formal toxicology data outside controlled lab settings.

Chemical Specifications

Property	Value
Molecular Formula	C₁₉H₂₇N₃O·HCl
Molecular Weight	~337.91 g/mol (hydrochloride salt)
CAS Number	77086-22-7
IUPAC Name	(+)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine
PubChem CID	1502

Structural Identifiers

Identifier	Data
SMILES	CN1C2=CC=CC=C2C3=C1C=CC=C3
InChIKey	SWIYHPRUBOZFLV-UHFFFAOYSA-N

Key Research Characteristics

Feature	Summary
Compound Type	NMDA receptor antagonist
Structural Interest	Mechanistic studies of glutamate receptors
Research Focus	Neuropharmacology, receptor binding, analytical studies
Documentation	CAS, molecular & structural data